What to Do About Recurrent Miscarriage? How to Replan IVF in the U.S., Mexico, and Japan

After experiencing one miscarriage, many people may regard it as an isolated event. But when similar experiences happen repeatedly, fertility planning often shifts from “When will I get pregnant?” to “Why can’t I stay pregnant?” At this point, rather than repeatedly trying to conceive naturally, it may be more helpful to review previous pregnancy experiences and look for factors that may affect pregnancy, including the embryo, uterine environment, and overall health.

In 2026, the American Society for Reproductive Medicine (ASRM) defined recurrent pregnancy loss as two or more pregnancy losses, which do not have to occur consecutively. For these cases, the evaluation does not focus only on the woman’s health, but also considers the timing of pregnancy loss, embryo chromosome status, uterine structure, and relevant factors involving both partners.

Why Does Recurrent Miscarriage Require Reevaluation?

Early pregnancy loss is closely associated with embryo chromosomal abnormalities, and its incidence is also strongly associated with maternal age. ASRM points out that approximately 50%–60% of early miscarriages are associated with embryo aneuploidy. Therefore, if chromosome testing was performed on the embryo or pregnancy tissue after a previous miscarriage, the results can provide important clues for subsequent evaluation.

However, embryo-related factors are not the whole picture. Uterine abnormalities, intrauterine adhesions, certain uterine fibroids or polyps, as well as conditions such as antiphospholipid syndrome, thyroid disease, and glucose metabolism disorders, may also be associated with recurrent miscarriage. In 2026, ASRM recommended that testing should be conducted based on individual circumstances rather than subjecting everyone to a large number of tests with no clear value.

How Can IVF Help With Replanning?

For those who have experienced multiple miscarriages and hope to replan their fertility through assisted reproduction, the value of IVF is not simply “helping achieve pregnancy,” but also allowing the eggs, sperm, embryos, and uterine environment to be evaluated separately.

Once the IVF process begins, doctors first develop an ovarian stimulation plan based on age, ovarian reserve, and previous treatment history. Eggs are then retrieved and fertilized with sperm to form embryos. After the embryos develop into the blastocyst stage, IVF-PGT can be used for embryo genetic evaluation, providing additional information about chromosomes and specific genetic factors. PGT in IVF-PGT is also an important technology to consider in modern embryo planning, but it cannot guarantee pregnancy or rule out every possible cause of miscarriage.

If an abnormality is found in the uterine cavity, factors that may affect embryo transfer need to be addressed first. If previous miscarriages were associated with certain systemic conditions, targeted management should also be carried out before attempting another pregnancy. The focus of this approach is to address embryo-related and maternal factors separately, rather than attributing all problems to a single factor.

After recurrent miscarriage, the most important change is often not simply “trying again,” but understanding what needs to be different the next time. The team founded by Dr. Nathan Zhang has provided overseas assisted reproductive consulting services for more than ten years, offering U.S. egg freezing, IVF in the U.S., and third-party reproduction services to those in need. With nearly 20 years of experience in overseas assisted reproduction, IVF USA recognized the diversity and personalization of reproductive needs and established a presence in the Mexican market early on, becoming the Chinese representative of Power Fertility Center, Mexico POWER Fertility Center (POWER IVF). Dr. Nathan Zhang’s services have now expanded beyond the United States to include IVF and egg freezing in Mexico, IVF and egg freezing in Japan and Thailand, as well as services in Taiwan and Hong Kong. We are committed to providing support and assistance as you move toward building the family you envision.